1.Basic information:
Product name: Indole-3-carbinol
Appreance: White fine powder
Chemical name: Indolemethanol; Indole-3-carbinol; 3-(Hydroxymethyl)indole; 3-Indolemethanol; 1H-Indol-3-ylmethanol; Indole-3-methanol; 1H-Indole-3-methanol
CAS No.:700-06-1
EINECS No.:211-836-2
Molecular formula :C9H9NO
Molecular weight:147.18
Purity: ≥ 99% by HPLC
Melting Point(mp):96-99°C
Loss on drying≤0.5%
Use : Nutraceuticals, or intermediate for medicines
Package : 25kg per paper barrel
Storage : Refrigerate (+4°C). Protect from light
2.Indole 3 methanol 3-Hydroxymethylindole
|
Content
|
Specification
|
Results
|
|
Assay(HPLC)
|
≥99.0%
|
99.4%
|
|
Melting range
|
96.0-100.0
|
97.2-98.7
|
|
Residue on ignition
|
0.1%
|
0.04%
|
|
PH
|
5-8
|
6-7
|
|
Loss on drying
|
1.0%
|
0.46%
|
|
Pb
|
5ppm
|
Conforms
|
|
Arsenic
|
1ppm
|
Conforms
|
|
Total plate count
|
500cuf/g
|
Conforms
|
|
Moulds
|
100cuf/g
|
Conforms
|
|
E .coli
|
Negative
|
Negative
|
|
Salmonella
|
Negative
|
Negative
|
3. Description
Indole 3 Carbinol is a type of Indole. Chemically, it is a metabolite of Glucobrassicin, which in turn is a hydrolytic product of Glucosinolates.
4.Function:
Indole-3-carbinol and its main metabolite diindoylmethane modulates several nuclear transcription factors resulting in a variety of biological and biochemical effects. Indole-3-carbinol works as a strong antioxidant, thereby protecting the DNA and other cell structures.
Chemopreventive
Indole-3-carbinol has chemopreventive activity and stimulates the production of detoxifying enzymes. The phytochemical protects against carcinogenic effect of pesticides and other toxins.
Anticancer
The anticancer effects of indole-3-carbinol and its metabolite diindoylmethane are the result of specific activities: inducing enzymes that metabolize carcinogens, enhancing DNA repair, inducing G1 cell cycle arrest and apoptosis. Indole-3-carbinol blocks estrogen receptor sites on the membranes of breast and other cells, thereby reducing the risk of cervical and breast cancer. Indole-3-carbinol increases the ratio of 2-hydroxyestrone to 16 alpha-hydroxyestrone and inhibits the 4-hydroxylation of estradiol. This is a favourable action of indole-3-carbinol because 16 alpha-hydroxyestrone and 4-hydroxyestrone have carcinogenic action. The estrogen metabolite 2-hydroxyestrone has protective against several types of cancer. Studies with animals have demonstrated that indole-3-carbinol reduced the carcinogenic affects of aflatoxins. The influence of indole-3-carbinol on the development of prostate cancer is less clear. Most studies report protective effects but a few studies indicate that indole-3-carbinol may promote prostate cancer formation. Treatment of skin cancer cells with ultraviolet-B results in the apoptosis of their apoptosis, a favorable effect that seems to be stimulated by indole-3-carbinol. Some studies also show a beneficial effect on the treatment of skin cancer.
Heart health
A few studies demonstrate the beneficial effects of indole-3-carbinol on lipid synthesis and platelet aggregation, suggesting that this phytochemical could help to improve heart health.
|
|
supplying Indole-3-carbinol powder, with high purity 99% by HPLC Images
|
